Gray
RJ, Nessim S, Khan SS, Denton T, Matloff JM.
Adverse 5-year outcome after coronary artery bypass surgery in blacks.
Arch Intern Med 1996;156(7):769-73.
This prospective study analyzed the outcomes for 3,728 coronary artery
bypass (CAB) surgery patients at Cedars-Sinai Medical Center in Los Angeles,
California, a private university affiliated teaching hospital, to determine
whether racial differences existed in survival outcome 5 years after coronary
artery bypass grafting surgery and to determine if existing differences
could be attributed to differences in preoperative characteristics. Data
on preoperative and postoperative characteristics were obtained from a
computerized database. Baseline data was collected from the patient’s
medical chart at the index hospital admission. Subsequent annual follow-up
data was obtained from these medical charts up until death. The sample
population had similar health care coverage. Blacks (60%) and whites (57%)
were primarily covered by Medicare and the remaining (38% of blacks and
42% of whites) had private medical insurance. A cardiac event was the
cause of death for 68% of blacks and 67% of whites.
The findings of this study indicate that “being black was a risk
factor for survival (hazard ratio, 1.97; P=.001). This was calculated
using a maximum follow-up period of 8 years (mean, 3.5 years).”
The results suggest that by “5 years after surgery, the unadjusted
risk of death in black patients is double that of white patients (36%
vs. 18%).” This “increased mortality risk associated with
being black remains statistically significant after adjustment for other
risk factors (adjusted hazard ratio, 2.10; P-to remove, .001).”
At one year after surgery, blacks had an 84.3% survival probability compared
to 92.1% for whites. By five years, the survival probability gap had increased
dramatically, as blacks had a 63.9% probability of surviving whereas whites
had an 81.8% survival probability. The authors state that “even
after adjusting for traditional risk factors, blacks have more than twice
the risk of death compared with white patients at 5 years.”
A potential limitation of this study is the small proportion of blacks
in the CAB surgery population (3%) compared to that “of the institution
(17%) and the Los Angeles metropolitan area (12%).” This problem,
“faced by other investigation of cardiac interventions in blacks,”
in fact “partly reflects the racially disparate use of CAB surgery.”
Furthermore, “the appearance of significant differences despite
small sample sizes, suggests a conservative estimate of true inter-group
differences.”
Unlike many previous studies, the sample population of this study was
composed of middle class blacks who were medically insured, therefore
eliminating a “potential variable in determining outcome and suggests
that factors other than affordability of health care are operative in
this group.”